Detalhe da pesquisa
1.
Minimizing higher-order aggregation maximizes iron mobilization by small molecules.
Nat Chem Biol
; 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38664586
2.
Small molecule mediated inhibition of RORγ-dependent gene expression and autoimmune disease pathology in vivo.
Immunology
; 147(4): 399-413, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26694902
3.
Discovery of biaryls as RORγ inverse agonists by using structure-based design.
Bioorg Med Chem Lett
; 26(10): 2459-2463, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27080181
4.
Discovery of novel pyrazole-containing benzamides as potent RORγ inverse agonists.
Bioorg Med Chem Lett
; 25(15): 2985-90, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26048789
5.
Structure-based design of low-nanomolar PIM kinase inhibitors.
Bioorg Med Chem Lett
; 25(3): 474-80, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25575657
6.
Discovery of biaryl carboxylamides as potent RORγ inverse agonists.
Bioorg Med Chem Lett
; 25(15): 2991-7, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26048806
7.
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism.
Bioorg Med Chem
; 21(14): 4011-9, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23647822
8.
Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors.
Bioorg Med Chem Lett
; 22(12): 4033-7, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22607669
9.
Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1.
Bioorg Med Chem Lett
; 22(5): 2070-4, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22326168
10.
Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Bioorg Med Chem Lett
; 21(18): 5633-7, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21798738
11.
Fluoroalkyl alpha side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2-CXCR1 dual antagonists.
Bioorg Med Chem Lett
; 19(5): 1431-3, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19196511
12.
Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region.
Bioorg Med Chem Lett
; 19(15): 4446-9, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19525110
13.
Synthesis and structure-activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists.
Bioorg Med Chem Lett
; 18(6): 1864-8, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18304809
14.
3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists.
Bioorg Med Chem Lett
; 18(1): 228-31, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18006311
15.
Synthesis and structure-activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists.
Bioorg Med Chem Lett
; 18(4): 1318-22, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18242983
16.
Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist.
J Med Chem
; 49(26): 7603-6, 2006 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17181143
17.
DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner.
J Neuroimmunol
; 283: 74-85, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26004161
18.
EC144 is a potent inhibitor of the heat shock protein 90.
J Med Chem
; 55(17): 7786-95, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22938030
19.
Pharmacological characterization of Sch527123, a potent allosteric CXCR1/CXCR2 antagonist.
J Pharmacol Exp Ther
; 322(2): 477-85, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17496166
20.
C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists.
Bioorg Med Chem Lett
; 17(13): 3778-83, 2007 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17459706